Longevity

Heart Disease Is the Leading Cause of Death for Women. Most Don't Know It.

Women worry most about breast cancer, but heart disease kills far more. Risk rises sharply after menopause — and the warning signs can differ.

June 12, 2026 · 5 min read

Heart disease is the leading cause of death for women in the United States, responsible for about one in five female deaths. Yet surveys show many women don’t know it — and many don’t recognise their own risk.

Why risk climbs after menopause

Before menopause, estrogen has protective effects on blood vessels and cholesterol. As levels fall:

  • LDL (“bad”) cholesterol tends to rise
  • Blood pressure often increases
  • Fat shifts toward the abdomen, which is linked to higher cardiovascular risk
  • Insulin resistance becomes more common

Early menopause (before 45), pregnancy complications such as preeclampsia or gestational diabetes, and autoimmune conditions like lupus or rheumatoid arthritis also raise a woman’s risk.

Heart attack symptoms in women

Chest pain or pressure is the most common symptom for both sexes. But women are somewhat more likely to also experience:

  • Shortness of breath
  • Nausea or vomiting
  • Pain in the jaw, neck, back or arm
  • Unusual fatigue
  • Lightheadedness

If you have these symptoms, call emergency services. Women are more likely than men to delay seeking help.

What lowers risk

The American Heart Association’s Life’s Essential 8 sums up the evidence:

  1. Eat a healthy diet
  2. Be physically active
  3. Don’t smoke or vape
  4. Get 7–9 hours of sleep
  5. Manage weight
  6. Control cholesterol
  7. Control blood sugar
  8. Control blood pressure

Know your numbers

Midlife is a good moment to check blood pressure, cholesterol and blood sugar, and to ask your clinician about your overall 10-year risk. Many of the most effective interventions — from blood pressure treatment to statins — work best when started before problems appear.

Sources

This article is for general information only and is not medical advice, diagnosis or treatment. Always consult a qualified health professional about your own situation.